PROGNOSTIC IMPACT OF REDUCED HER2 PROTEIN EXPRESSION IN POST-NEOADJUVANT THERAPY RESECTION SPECIMENS: A SINGLE INSTITUTION EXPERIENCE AND REVIEW OF THE LITERATURE

Background: Retesting for Human epidermal growth factor receptor-2 (HER2) in post-neoadjuvant therapy resection is variable, and data is bismarck armb?nd conflicting regarding the prognostic significance of changes in HER2 expression pre and post therapy.Methods: We identified 104 patients with localized HER2 IHC 3+ breast cancer who received neoad

Finding a given location can be based on a variety of strategies, for example on the estimation of spatial relations between landmarks, called spatial orientation.In galliform birds, spatial orientation has been demonstrated convincingly in very young domestic chicks.We wanted to know whether adult Japanese quails (Coturnix coturnix japonica) witho

Australian trans youth seeking medical treatment for gender dysphoria can encounter significant legal barriers to healthcare.Legal requirements for obtaining valid consent to gender-affirming care, first established in 2004, mean that an application to the Family Court is required in many cases before treatment can be provided.The development of Au

Even if the polarizing discussion about instructive and constructive teaching approaches is widely overcome, some misapprehensions still seem to distort the discourse.Thereby thesis, like the future of teaching would only lie in self-directed, process-oriented, casuistic and interdisciplinary learning (predominantly constructivist paradigms) and in